|Cell phone number with international prefix: +421-2-32295709|
|Affiliation: Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences,
Dubravska cesta 9, 84505 Bratislava, Slovakia
|Year of the PhD title: 1992|
|Personal web page: http:// www.sav.sk/index.php?lang=en&doc=user-org-user&user_no=209|
|Previous COST participation: Yes|
List of 10 selected publications within last 5 years
|1. Antioxidant action of 3-mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid, an efficient aldose reductase inhibitor, in a 1,1 ‘-diphenyl-2-picrylhydrazyl assay and in the cellular system of isolated erythrocytes exposed to tert-butyl hydroperoxide.
By: Prnova, Marta Soltesova; Ballekova, Jana; Majekova, Magdalena; et al.
REDOX REPORT Volume: 20 Issue: 6 Pages: 282-288
|2. Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA1) by rutin derivatives
By: Viskupicova, Jana; Majekova, Magdalena; Horakova, Lubica
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY Volume: 36 Issue: 2 Pages: 183-194
|3. Rutin stimulates sarcoplasmic reticulum Ca(2+-)ATPase activity (SERCA1) and protects SERCA1 from peroxynitrite mediated injury
By: Viskupicova, Jana; Strosova, Miriam K.; Zizkova, Petronela; Majekova, Magdalena; et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY Volume: 402 Issue: 1-2 Pages: 51-62
|4. Identification of Novel Aldose Reductase Inhibitors Based on Carboxymethylated Mercaptotriazinoindole Scaffold
By: Stefek, Milan; Prnova, Marta Soltesova; Majekova, Magdalena; et al.
JOURNAL OF MEDICINAL CHEMISTRY Volume: 58 Issue: 6 Pages: 2649-2657
|5. 2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent
By: Milackova, Ivana; Prnova, Marta Soltesova; Majekova, Magdalena; et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Volume: 30 Issue: 1 Pages: 107-113
|6. [5-(Benzyloxy)-1H-indol-1-yl]acetic acid, an aldose reductase inhibitor and PPAR gamma ligand
By: Prnova, Marta Soltesova; Majekova, Magdalena; Milackova, Ivana; et al.
ACTA BIOCHIMICA POLONICA Volume: 62 Issue: 3 Pages: 523-528
|7. Substituted Pyridoindoles as Biological Antioxidants: Drug Design, Chemical Synthesis, and Biological Activity
By: Kovacikova, Lucia; Majekova, Magdalena; Stefek, Milan
Edited by: Armstrong, D
ADVANCED PROTOCOLS IN OXIDATIVE STRESS III Book Series: Methods in Molecular Biology Volume: 1208 Pages: 313-327
|8. Novel quercetin derivatives in treatment of peroxynitrite-oxidized SERCA1
By: Zizkova, Petronela; Blaskovic, Dusan; Majekova, Magdalena; et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY Volume: 386 Issue: 1-2 Pages: 1-14
|9. Novel Dibenzothiepins with Antibiofilm Activity Demonstrated by Microbiological Assays and Molecular Modeling
By: Stecoza, Camelia Elena; Majekova, Magdalena; Majek, Pavol; et al.
CURRENT ORGANIC CHEMISTRY Volume: 17 Issue: 2 Pages: 113-124
|10. Polyphenol fatty acid esters as serine protease inhibitors: a quantum-chemical QSAR analysis
By: Viskupicova, Jana; Danihelova, Martina; Majekova, Magdalena; et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Volume: 27 Issue: 6 Pages: 800-809
Main skills and expertise (up to 5)
|1. drug design|
|2. molecular docking|
|3. molecular dynamics|
|4. ADMET calculations|
Main equipment/facilities available in the participants’ lab (up to 5)
|1. enzyme assays (aldo-keto reductases AKR1B1, AKR1A1, AKR1B10; glucosidase)|
|2. permeation of organic compounds to red blood cells, rat lens; affecting the sorbitol level in model of diabetes in vitro (isolated rat lens and RBC)|
|3. measuring of oxidative damage of proteins and lipids and AO activity of organic compounds|
|4. quantum chemical, molecular mechanics and molecular dynamics methods, virtual screening|
|5. interaction of organic compounds with SERCA1|
Short personal activity proposal for the COST Action CA15135 (max 1000 characters)
Our team has much experience in virtual and biological screening of indolic compounds for therapy of chronic diabetic complications. Several compounds showed multi-target effect towards proteins important in development of other chronic diseases. We offer our experience in design and testing of new indole compounds acting as aldo-keto reductase inhibitors and radical scavengers for development of potential drugs for chronic diseases.
On the other hand, we would appreciate collaboration with teams possessing experience in testing for other multi-target properties, mainly towards the proteins involved in inflammation, cancer and neurodegenerative processes.
We have also compiled the database of compounds with indole moiety (several hundreds) with ADMET parameters involved.
Work Group preference: score from 1 (preferred) to 4 (not preferred)
|Work Group of the CA15135 COST Action||Score|
|WG1: Development of new chemical entities||1|
|WG2: Selection of biological targets and assessment of biological data||2|
|WG3: Development of chemical databases||3|
|WG4: Development of Computational methods for multiple ligand design and discovery||4|