WG1 Leader
Dr. Danijel Kikelj – Faculty of Pharmacy University of Ljubljana Askerceva 71000 Ljubljana (Slovenia) – danijel.kikelj@ffa.uni-lj.si
WG1 Objectives
This Working Group will provide to Chemoteca new chemical entities, i.e. small organic molecules, preferably based on privileged scaffolds, obtained by means of synthetic traditional and advanced methods or by extraction from natural sources, such as plants, functional foods and microorganisms. This WG will also synthesize the multi-target ligands designed in WG 4.
WG1 Tasks
- up-to-dating synthetic routes applied to drug discovery programs;
- optimizing protocols for easy extractions of essential oils and nutraceuticals;
- synthesis, purification and physico-chemical characterization of bioactive compounds.
WG1 Milestones
- compiling the list of “’in-house” chemical entities;
- updating during the Action the list with new synthetic and/or extracted bioactive compounds;
- scaling up fine-tuning the decoration of the scaffolds, extraction in function of the predicted and/or experimentally determined activities or affinities toward multiple targets.
WG1 Deliverables
- reviewing and optimizing synthetic routes and extraction protocols to obtain compounds of interest;
- starting a chemical catalog program;
- providing with new chemical entities guided by scientific interactions with biologists and computational chemists belonging to other WGs.
WG1 Affiliations
| Firstname | Lastname | Position | Country |
| Akram | Alian | MC Member | IL |
| Constantinos | Athanassopoulos | MC Substitute | EL |
| Andrej | Bohac | MC Member | SK |
| Maria Laura | Bolognesi | MC Member | IT |
| Fernanda | Borges | MC Member | PT |
| Maurizio | Botta | MC Substitute | IT |
| Bruno | Botta | MC Substitute | IT |
| Luc | Demange | MC Member | FR |
| Vladimir | Dobricic | MC Substitute | RS |
| Slavica | Filipic | MC Member | RS |
| Alfonso T. | Garcia-Sosa | MC Member | EE |
| Alexandra | Gaspar | MC Substitute | PT |
| Gilles | HANQUET | MC Member | FR |
| Danijel | Kikelj | MC Member | SI |
| Jan | Korabecny | MC Substitute | CZ |
| Vincent | Lisowski | MC Substitute | FR |
| Jose | Marco-Contelles | MC Substitute | ES |
| Celine J. | Marmion | MC Member | IE |
| Dariusz | Matosiuk | MC Member | PL |
| Peter | Matyus | MC Member | HU |
| Florence | Mccarthy | MC Substitute | IE |
| Christiana A. | Mitsopoulou | MC Member | EL |
| Christa | Müller | MC Member | DE |
| Kamil | Musilek | MC Member | CZ |
| Christophe | Rochais | MC Substitute | FR |
| Bart | Roman | MC Member | BE |
| Claire | Shoemake | MC Member | MT |
| Eddy | Sotelo | MC Member | ES |
| Gary | Stack | MC Member | IE |
| Holger | Stark | MC Member | DE |
| Pavel | Starkov | MC Member | EE |
| Magne Olav | Sydnes | MC Member | NO |
| Tamara | Todorovic | MC Substitute | RS |
| Tihomir | Tomasic | MC Member | SI |
| Jan | Vacek | MC Member | CZ |
| Jarmila | Vinšová | MC Substitute | CZ |
| Ivo | Grabchev | MC Member | BG |
| David | Magri | MC Member | MT |
