Mu.Ta.Lig - COST ACTION CA15135

Prof. Dariusz MATOSIUK

14 June 2016


General information

Name: Dariusz
Surname:  Matosiuk
Cell phone number with international prefix: +48 501281474
Country: Poland
Affiliation: Faculty of Pharmacy, Medical University of Lublin
Gender: F □ M X
Year of the PhD title: 1991
Personal web page: http://
Previous COST participation: No □ Yes X


List of 10 selected publications within last 5 years

1.      Chem. Rev. 113 (7) (2013), 4905-4979. Thirumurugan P., Matosiuk D., Jóżwiak K.: Click chemistry reaction for diverse biological applications.
2.      Curr, Med. Chem. 20 (27) (2013), 3317-3338. Skrzypczak M., Kapka-Skrzypczak L., Cyranka M., Treeck O., Wróbel A.,  Matosiuk D.: Nuclear estrogen receptors co-activation mechanisms.
3.      J. Pharm. Biomed. Anal. 87 (2014), 313-325. Drączkowski P., Matosiuk D., Jóźwiak K.: Isothermal titration calorimetry in membrane protein research.
4.      Bioorg. Med. Chem. 22 (2) (2014), 787-795. Kaczor A.A., Karczmarzyk Z., Fruziński A., Pihlaja K., Sinkkonen J., Viinamaki  K., Kronbach Ch., Unverferth K., Poso A., Matosiuk D.: Structural studies, homology modeling and molecular docking of novel noncompetitive antagonists of GluK1/GluK2 receptors.
5.      Bioorg. Med. Chem. 22 (24) (2014), 6846-6856. Jozwiak K., Targowska-Duda K., Kaczor A., Kozak J., Ligeza A., Szacon E., Wrobel T., Budzynska B., Biala G., Fornal E., Poso A., Wainer W.I., Matosiuk D.: Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextrometorphane derivatives as non-competitive inhibitors of a3b4 nicotinic acetylcholine receptor.
6.      J. Chem. Inf. Model. 55 (11) (2015), 2421-2434. Bartuzi D., Kaczor A.A., Matosiuk D.: Activation and allosteric modulation of human mu opioid receptor in molecular.
7.      Arch. Biochem. Biophys. 592 (2016), 1-4. Janik E., Bednarska J., Zubik M., Sowiński K., Luchowski R., Grudziński W., Matosiuk D., Gruszecki W.I.: The xanthophyll cycle pigments, violaxanthin and zeaxanthin, modulate molecular organization of the photosynthetic antenna complex LHCII.
8.      Biochem. Biophys. ActaGen. Subj. 1860 (5) (2016), 967-974. Drączkowski P., Tomaszuk A., Halczuk P., Strzemski M., Matosiuk D., Jóźwiak K.: Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry.
9.      J. Chem. Inf. Model. (2016), accepted for publivation. Bartuzi D., Kaczor A.A., Matosiuk D.: Interplay between two allosteric sites and their influence on agonist binding in human mu opioid receptor.
10.  J. Enzyme Inhib. Med. Chem. (2016), accepted for publication. Wróbel T., Kiełbus M., Kaczor A.A., Krystof V., Karczmarzyk Z., Wysocki W., Fruzinski A., Król S., Grabarska A.,  Stepulak A., Matosiuk D.: Discovery of nitroaryl urea derivatives with antiproliferative properties.


Main skills and expertise (up to 5)

1.      Organic and heterocyclic synthesis.
2.      Organic compounds structure elucidation.
3.      Molecular modeling of ligand-protein interactions
4.      Physicochemical properties affecting bioavailability.
5.      Thermodynamics of ligand-protein interactions.


Main equipment/facilities available in the participants’ lab (up to 5)

1.      300 (C,H) and 600 (multinuclear)MHz NMR
2.      UPHPLC with different detectors (MS, CDI, corona, UV)
3.      Microcalorymetry titration (MCT), surface plasmon resonance (SPR), patch-clamp units
4.      IR/Raman miscroscops,  confocal microscop
5.      96 and 264-cores clasters for molecular modeling and molecular dynamics calculation


Short personal activity proposal for the COST Action CA15135 (max 1000 characters)

Within the COST Action CA15135 I would be interested in discussing possibility of multitarget and multieffect ligands development with some special interest in:

1)      Combining antinociceptive and antidepressant activity;

2)      Allosteric and dualsteric  action on opioid and dopaminergic receptors;

3)      Development of the computation methods for multiple ligand design and discovery.

Natural continuation of the following points of interest would be also involvement in development of chemical and biological databases.


Work Group preference: score from 1 (preferred) to 4 (not preferred)

Work Group of the CA15135 COST Action Score
WG1: Development of new chemical entities X
WG2: Selection of biological targets and assessment of biological data  
WG3: Development of chemical databases  
WG4: Development of Computational methods for multiple ligand design and discovery X