Mu.Ta.Lig - COST ACTION CA15135

Prof. Emmanuel MIKROS

14 June 2016


General information

Name: Emmanuel
Surname: Mikros
Cell phone number with international prefix: +
Country: Greece
Affiliation: University of Athens
Gender: F □ M X
Year of the PhD title: 1988
Personal web page:
Previous COST participation: No □ Yes X


List of 10 selected publications within last 5 years

1. Byrne B. et al Nature Communications 2016 (in press) Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity,
2. Myrianthopoulos V. et al Eur. J. Med Chem.2016  (in press) Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation
3. Petrakis TG et al Seminars in Cancer Biology 12/2015 Exploring and exploiting the systemic effects of deregulated replication licensing
4. Guldbrandsen, N., et al  Journal of Natural Products, 2015, 78, 977-986. NMR-Based Metabolomic Study on Isatis tinctoria: Comparison of Different Accessions, Harvesting Dates, and the Effect of Repeated Harvesting
5. Mavrokefalos, N., et al Planta Medica, 2015, 81 507-516 Discovery of the glycogen phosphorylase-modulating activity of a resveratrol glucoside by using a virtual screening protocol optimized for solvation effects
6. Karena, E., Molecular Microbiology, 2015, 98, 502-517 Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ
7. Kostidis, S., & Mikros, E.  eMagRes. 2015, 4, 57-68. NMR Studies of Inborn Errors of Metabolism
8. Halabalaki M, et al Current Opinion in Biotechnology 2014, 25, 1-7  Recent advances and new strategies in the NMR-basedidentification of natural products
9. Myrianthopoulos V,  et al ACS Med. Chem. Lett., 2013, 4, 22-26 Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases
10. Pechlivanis A, et al  J. Proteome Res. 2013, 12, 470–480. 1H NMR Study on the Short- and Long-Term Impact of Two Training Programs of Sprint Running on the Metabolic Fingerprint of Human Serum





Main skills and expertise (up to 5)

1.      NMR Spectroscopy
2.      Drug Design In silico screening
3.      Structural chemistry
4.      Metabolomics
5.      Natural Products


Main equipment/facilities available in the participants’ lab (up to 5)

1.      NMR 600 MHz-400 MHz
2.      Orbitrap MS
3.      Supercritical Fluid Chromatography MS (SFC-MS)
4.      Countercurrent Partition Chromatograph (CPC)
5.      Schrodinger Drug Discovery Suites


Short personal activity proposal for the COST Action CA15135 (max 1000 characters)

We can participate in WG4 for the development of Structure Based Drug Design, Molecular Simulations, in silico screening and Structure Activity Relationships. In our group specific calculation protocols have been established and used in order to design new molecules with desired biological activity. We have gained experience through the systematic study of receptors like Kinases (CDKs, GSK3, DYRK, CK1), Nuclear Receptors (ERα, ERβ, AR), Epigenetic targets (bromodomains, UHRF) and membrane transporters (UapA, XanQ).

We can also provide some expertise in WG3 as we have an in-house library organized and barcoded containing ~2000 molecules.


Work Group preference: score from 1 (preferred) to 4 (not preferred)

Work Group of the CA15135 COST Action Score
WG1: Development of new chemical entities 3
WG2: Selection of biological targets and assessment of biological data 4
WG3: Development of chemical databases 2
WG4: Development of Computational methods for multiple ligand design and discovery 1