General information
| Name:Fernanda |
| Surname:Borges |
| E-mail:fborges@fc.up.pt |
| Cell phone number with international prefix: + 351 220402560 |
| Country:Portugal |
| Affiliation:Faculty of Sciences, University Porto |
| Gender: F x M □ |
| Year of the PhD title: 1995 |
| Personal web page: http://under construction http://orcid.org/0000-0003-1050-2402 |
| Previous COST participation: No □ Yes x |
List of 10 selected publications within last 5 years
| 1. T. Silva, J. Teixeira, F. Remião, F. Borges*, Alzheimer’s disease, cholesterol, and statins: the junctions of important metabolic pathways, Angew. Chem. Int. Ed. Engl., 52 (2013) 1110-1121 |
| 2. J. Teixeira, T. Silva, S. Benfeito, A. Gaspar, E.M. Garrido, J. Garrido, F. Borges*, Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids, Eur. J. Med. Chem., 62 (2013) 289-296 |
| 3. A. Gaspar, M.J. Matos, J. Garrido, E. Uriarte, F. Borges*, Chromone: a valid scaffold in Medicinal Chemistry, Chem. Rev., 114 (2014) 4960–4992 |
| 4. F. Mura, T. Silva, C. Castro, F. Borges*, M.C. Zuñiga, J. Morales, C. Olea-Azar, New insights into the antioxidant activity of hydroxycinnamic and hydroxybenzoic systems: spectroscopic, electrochemistry, and cellular studies, Free Radic. Res., 48 (2014) 1473-1484 |
| 5A Gaspar, N Milhazes, L Santana, E Uriarte, F.Borges , MJ.Matos Oxidative stress and neurodegenerative diseases: looking for a therapeutic solution inspired on benzopyran chemistry. Curr Top Med Chem. 15(2015) 432-45 |
| 6. M Andrade, S Benfeito, P Soares, DM e Silva, J Loureiro, A Borges, F Borges*, M Simões Fine-tuning of the hydrophobicity of caffeic acid: studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli RSC Advances, 5 (2015), 53915-53925.
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| 7. MJ Matos, F Rodríguez-Enríquez, F Borges, L Santana, E Uriarte, M Estrada, MI Rodríguez-Franco, R Laguna, D Viña. 3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases. ChemMedChem;10 (2015):2071-9 |
| 8. D Chavarria, T Silva, D Martins, J Bravo, T Summavielle, J Garrido, F. Borges*Exploring cinnamic acid scaffold: development of promising neuroprotective lipophilic antioxidants MedChemComm 6 (2015), 1043-53
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| 9. T Silva, J Bravo, T Summavielle, F Remião, C Pérez, C Gil, A Martínez, F. Borges* Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity RSC Advances 5 (2015), 15800-1581 |
| 10. F Cagide, T Silva, J Reis, A Gaspar, F Borges*, LR Gomes, JN Low Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry Chemical Communications 2015, 51 (14), 2832-2835 |
Main skills and expertise (up to 5)
| 1.Design and development of small molecule libraries |
| 2.Discovery of new leads; lead optimization process |
| 3.Enzymatic and antioxidant screenings |
| 4.Evaluation of physicochemical properties; Nanomedicine (nanoengineered solutions) |
| 5.Synthesis of metabolites. Experimental validation of bioinformatics data. |
Main equipment/facilities available in the participants’ lab (up to 5)
| 1. Synthetic laboratory equipment (microwave synthesizer, Automatic flash chromatography, etc) |
| 2. Analytical Facilities (HPLC, electrochemical apparatus etc) |
3. Enzymatic and antioxidant screening (microplate reader, etc) |
| 4. Structural elucidation ( NMR, EM, HPLC-DAD, HPLC-ESI-MS, HPLC–DAD/QTOF-MS) |
| 5. |
Short personal activity proposal for the COST Action CA15135 (max 1000 characters)
|
1- Library of benzopyrane ( coumarin and chromones) based compounds
2- Library of cinnamic and benzoic based compounds.
3- Synthesis of metabolites
4- Evaluation of physicochemical properties (redox properties, solubility, stability, lipophilicity, etc)
5- Enzymatic assays (e.g. MAO-A, MAO-B, acetyl and butyrylcholinesterase, Xanthine oxidase). Mechanistic enzymatic studies. Screening in other targets by collaborative network. Antioxidant screening.
6- Toxicological assays performed by collaborative network.
7- Host PhD students and post-doctoral researchers
8- Organization of one of the actions meeting
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Work Group preference: score from 1 (preferred) to 4 (not preferred)
| Work Group of the CA15135 COST Action | Score |
| WG1: Development of new chemical entities | 1 |
| WG2: Selection of biological targets and assessment of biological data | 2 |
| WG3: Development of chemical databases | 3 |
| WG4: Development of Computational methods for multiple ligand design and discovery | 4 |
