Mu.Ta.Lig - COST ACTION CA15135

Prof. Fernanda BORGES

14 June 2016


General information

Cell phone number with international prefix: + 351 220402560
Affiliation:Faculty of Sciences, University Porto
Gender: F x M
Year of the PhD title: 1995
Personal web page: http://under construction
Previous COST participation: No □ Yes x


List of 10 selected publications within last 5 years

1. T. Silva, J. Teixeira, F. Remião, F. Borges*, Alzheimer’s disease, cholesterol, and statins: the junctions of important metabolic pathways, Angew. Chem. Int. Ed. Engl., 52 (2013) 1110-1121
2. J. Teixeira, T. Silva, S. Benfeito, A. Gaspar, E.M. Garrido, J. Garrido, F. Borges*, Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids, Eur. J. Med. Chem., 62 (2013) 289-296
3. A. Gaspar, M.J. Matos, J. Garrido, E. Uriarte, F. Borges*, Chromone: a valid scaffold in Medicinal Chemistry, Chem. Rev., 114 (2014) 4960–4992
4. F. Mura, T. Silva, C. Castro, F. Borges*, M.C. Zuñiga, J. Morales, C. Olea-Azar, New insights into the antioxidant activity of hydroxycinnamic and hydroxybenzoic systems: spectroscopic, electrochemistry, and cellular studies, Free Radic. Res., 48 (2014) 1473-1484
5A Gaspar, N Milhazes, L Santana, E Uriarte, F.Borges , MJ.Matos Oxidative stress and neurodegenerative diseases: looking for a therapeutic solution  inspired on benzopyran chemistry. Curr Top Med Chem. 15(2015) 432-45
6. M Andrade, S Benfeito, P Soares, DM e Silva, J Loureiro, A Borges, F Borges*, M Simões Fine-tuning of the hydrophobicity of caffeic acid: studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli RSC Advances, 5 (2015), 53915-53925.


7. MJ Matos, F Rodríguez-Enríquez, F Borges, L Santana, E Uriarte, M Estrada, MI Rodríguez-Franco, R Laguna, D Viña. 3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases. ChemMedChem;10 (2015):2071-9
8. D Chavarria, T Silva, D Martins, J Bravo, T Summavielle, J Garrido, F. Borges*Exploring cinnamic acid scaffold: development of promising neuroprotective lipophilic antioxidants MedChemComm 6 (2015), 1043-53


9. T Silva, J Bravo, T Summavielle, F Remião, C Pérez, C Gil, A Martínez, F. Borges* Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity RSC Advances 5 (2015), 15800-1581
10. F Cagide, T Silva, J Reis, A Gaspar, F Borges*, LR Gomes, JN Low Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry Chemical Communications 2015, 51 (14), 2832-2835


Main skills and expertise (up to 5)

1.Design and development of small molecule libraries
2.Discovery of new leads; lead optimization process
3.Enzymatic and antioxidant screenings
4.Evaluation of physicochemical properties; Nanomedicine (nanoengineered solutions)
5.Synthesis of metabolites. Experimental validation of bioinformatics data.


Main equipment/facilities available in the participants’ lab (up to 5)

1. Synthetic laboratory equipment (microwave synthesizer, Automatic flash chromatography, etc)
2. Analytical Facilities (HPLC, electrochemical apparatus etc)

3. Enzymatic and antioxidant screening (microplate reader, etc)

4. Structural elucidation ( NMR, EM, HPLC-DAD, HPLC-ESI-MS, HPLC–DAD/QTOF-MS)



Short personal activity proposal for the COST Action CA15135 (max 1000 characters)


1-      Library of benzopyrane ( coumarin and chromones) based compounds


2-      Library of cinnamic and benzoic based compounds.


3-      Synthesis of metabolites


4-      Evaluation of physicochemical properties (redox properties, solubility, stability, lipophilicity, etc)


5-      Enzymatic assays (e.g. MAO-A, MAO-B, acetyl and butyrylcholinesterase, Xanthine oxidase). Mechanistic enzymatic studies. Screening in other targets by collaborative network. Antioxidant screening.


6-      Toxicological assays performed by collaborative network.


7-      Host PhD students and post-doctoral researchers


8-      Organization of  one of the actions meeting




Work Group preference: score from 1 (preferred) to 4 (not preferred)

Work Group of the CA15135 COST Action Score
WG1: Development of new chemical entities 1
WG2: Selection of biological targets and assessment of biological data 2
WG3: Development of chemical databases 3
WG4: Development of Computational methods for multiple ligand design and discovery 4