Mu.Ta.Lig - COST ACTION CA15135


14 June 2016

General information

Name: Ivo
Surname: Grabchev
Cell phone number with international prefix: +359 888264176
Country: Bulgaria
Affiliation: University of Sofia, Faculty of Medicine
Gender: M
Year of the PhD title: 1991
Personal web page: http://
Previous COST participation: Yes


List of 10 selected publications within last 5 years

1.       I. Grabchev, D. Staneva, I. Betcheva, Fluorescent dendrimers as sensors for biologically important metal ions, Curent Medical Chemistry, 19 (2012) 4976-4983
2.       D. Staneva, E.Vasileva-Tonkova, M.S. I. Makki, A. Asiri,  I. Grabchev,  Combination of sensor potential and antimicrobial activity of a new 4-(2-dimethylaminoethyloxy)-N-buthyl-1,8-naphthalimide, J. Molecular Structure, 1071, 2014, 88-94

3.       D. Staneva, E. Vasileva-Tonkova, M. S. I. T. Makki, T. R. Sobahi, R. M. Abdulrahman, A. M. Asiri, I. Grabchev, Synthesis, photophysical and antimicrobial activity of new water soluble ammonium quaternary benzanthrone in solution and in polylactide film, Journal of Photochemistry and Photobiology B: Biology, 2015, 143, 44-51

4.       D. Staneva, E. Vasileva-Tonkova, M. S.I. Makki, T. R. Sobahi, R. M. Abdеl-Rahman, I. H. Boyaci, A.M. Asiri, I. Grabchev, Synthesis and spectral characterization of a new PPA dendrimer modified with 4-bromo-1,8-naphthalimide and in vitro antimicrobial activity of its Cu(II) and Zn(II) metal complexes, Tetrahedron, 71, 2015, 1080-1087

5.      D. Staneva, D. Atanasova, E. Vasileva-Tonkova, V. Lukanova, I. Grabchev,  A cotton fabric modified with a hydrogel containing ZnO nanoparticles. Preparation and properties study, Applied Surface Science, 2015, 345, 72-80

6.       I. Grabchev, S.Yordanova, E. Vasileva-Tonkova, P. Bosch, S. Stoyanov, Poly(propylenamine) dendrimers modified with 4-amino-1,8- naphthalimide: Synthesis, characterization and in vitro microbiological tests of their Cu(II) and Zn(II) complexes, Inorganica Chimica Acta 438 (2015) 179–188

7.       S. Yordanova, H. T. Temiz, I.H. Boyaci, S. Stoyanov, E. Vasileva-Tonkova, A. M. Asiri, I. Grabchev, Synthesis, characterization and in vitro antimicrobial activity of a new blue fluorescent Cu(II) metal complex of bis-1,8-naphthalimide, Journal of Molecular Structure 1101 (2015) 50-56.

8.      D. Staneva, I. Grabchev, E.Vasileva-Tonkova, R. Kukeva, R. Stoyanova, Synthesis, characterization and in vitro antimicrobial activity of a new fluorescent tris-benzo[de]anthracen-7-one and its Cu(II) complex, Tetrahedron 72 (2016) 2440-2446


9.       I. Grabchev, S.Yordanova, E. Vasileva-Tonkova, M. Cangiotti, A. Fattori, R. Alexandrova, S. Stoyanov, M.F. Ottaviani, A novel benzofurazan-cyclam conjugate and its Cu(II) complex:Synthesis, characterization and in vitro cytotoxicity and antimicrobial Activity, Dyes and Pigments 129 (2016) 71-79
10.   I. Grabchev, S. Yordanova , P. Bosch, E. Vasileva-Tonkova. R.Kukeva, S. Stoyanov, R. Stoyanova, Structural characterization of 1,8-naphthalimides and in vitro microbiological activity of their Cu(II) and Zn(II) complexes, Journal of Molecular Structure 1130 (2017) 974-983

Main skills and expertise (up to 5)

1.Organic synthesis and characterization
2. Dendrimers,
3. Metal complexes
4. Photophysics
5. Bioactive compounds

 Main equipment/facilities available in the participants’ lab (up to 5)

1.Basic equipment of organic synthesis
2. UV-VIS spectrophotometer (Thermo);
3. Spectrofluorometer (Varian) with attachments for measurements in the solid phase at various temperatures and for polarization spectra of reflection at different angles
4. Highly sensitive equipment to obtain the monolayers (LAURELL) with a full range of lamps and filters are available in the team laboratory

 Short personal activity proposal for the COST Action CA15135 (max 1000 characters)


Dendrimer molecules contain a large number of closely located functional groups in their structure. If these groups are functionalized with a biologically active substance, it can be expected the increase in biological activity of the dendrimers as compared with the compounds of low molecular weight.

During this campaign we plan to accomplish the following tasks:

1.      Synthesis of dendrons and dendrimers with antimicrobial properties

2.      Synthesis of metallodendrimers with antimicrobial properties

3.      Synthesis and study of thin films of polylactide with incorporated low molecular weight compounds and dendrimers with antimicrobial activityPreparation and study of textile materials with antibacterial activity

4.      Microbiological studies of the newly synthesized compounds

The antimicrobial activity of the newly synthesized compounds and composite materials based on polylactide and textiles will be explored in vitro against different model Gram (+) and Gram (-) bacteria and fungal strains by the method of diffusion in solid nutrient medium and quantified by determining the minimum inhibitory concentration (MIC) and the minimum bactericide concentration (MBC). In assessing the activity of the substances will be used standards – antibiotics with known effectiveness against relevant microorganisms. More detailed studies with selected dendrimeric compounds will be carried out related to study their effect on the growth and cell membrane properties of model Gram (+) and Gram (-) bacterial strains.


 Work Group preference: score from 1 (preferred) to 4 (not preferred)

Work Group of the CA15135 COST Action Score
WG1: Development of new chemical entities X
WG2: Selection of biological targets and assessment of biological data  
WG3: Development of chemical databases  
WG4: Development of Computational methods for multiple ligand design and discovery  


I agree to publish the above data on the COST Action web site. YES X