Mu.Ta.Lig - COST ACTION CA15135


5 December 2016


General information

Name: Pavel
Surname: Starkov
Cell phone number with international prefix: +372 5686 9210
Country: Estonia
Affiliation: Tallinn University of Technology (TUT)
Gender: Male
Year of the PhD title: 2011
Personal web page:
Previous COST participation: No


List of 10 selected publications within last 5 years

Lanigan, R. M.; Karaluka, V.; Sabatini, M.; Starkov, P.; Badland, M.; Boulton, L.; Sheppard, T. D. Direct Amidation of Unprotected α-Amino Acids Using B(OCH2CF3)3.

Chem. Commun. 2016, 52, accepted.

Starkov, P.; Jamison, T. F.; Marek, I. Electrophilic Amination: The Case of Nitrenoids.

Chem. Eur. J. 2015, 21, 5278.

Lanigan, R. M.; Starkov, P.; Sheppard, T. D. Direct Synthesis of Amides from Carboxylic Acids and Amines Using B(OCH2CF3)3.

J. Org. Chem. 2013, 78, 4512.

Starkov, P.; Rota, F.; D’Oyley, J. M.; Sheppard, T. D. Catalysis of Electrophilic Halogenation of Silyl-Protected and Terminal Alkynes: Trapping Gold(I) Acetylides vs. a Brønsted Acid-Promoted Reaction.

Adv. Synth. Catal. 2012, 354, 3217.

Starkov, P.; Sheppard, T. D. Borate Esters as Convenient Reagents for Direct Amidation of Carboxylic Acids and Transamidation of Primary Amides.

Org. Biomol. Chem. 2011, 9, 1320.

Körner, C.; Starkov, P.; Sheppard, T. D. An Alternative Approach to Aldol Reactions: Gold-Catalyzed Formation of Boron Enolates from Alkynes.

J. Am. Chem. Soc. 2010, 132, 5968.


Main skills and expertise (up to 5)

1.      Synthetic organic chemistry
2.      Homogenous catalysis
3.      Cell culture, immunofluorescence imaging
4.      High throughput/high content screening
5.      Cell division/cytokinesis



Main equipment/facilities available in the participants’ lab (up to 5)

Aside from typical synthetic chemistry and cell culture facilities, we have direct access to several shared facilities at TUT within our department. These include:

1.      NMR 400 and 800 MHz
2.      Biacore
4.      Imaging (confocal, TIRF, FRAP, photobleaching, live imaging)


Short personal activity proposal for the COST Action CA15135 (max 1000 characters)


1.      ITN – CA15135 has a high potential to develop into a well-diversified ITN. While such applications take a long time and may not always be awarded on the first attempt. I will be ready to take part in preparing the effort from the start.

2.      WG1+WG2 Synergy – I believe that optimal synergy within the CA15135 framework would be achieved through an effective crosstalk of several working groups. I will be glad to initiate/organise a synergy workshop at Tallinn U of Tech to identify and maximise such synergy possibilities early in the process.



1.      I have initiated work on multifunctional cell penetrant ligands in my group at TUT in early 2016; the work is supported by the Starting Grant from the Estonian Research Council secured last year. We use both cell biology and synthetic chemistry approaches.

2.      We are developing a biocompatible/supramolecular scaffolding to allow for multiheterofunctional activity to be realised within the context of the living cell.


Work Group preference: score from 1 (preferred) to 4 (not preferred)

Work Group of the CA15135 COST Action Score
WG1: Development of new chemical entities 1
WG2: Selection of biological targets and assessment of biological data 1
WG3: Development of chemical databases 3
WG4: Development of Computational methods for multiple ligand design and discovery 3