|Cell phone number with international prefix: +34-639888525|
|Affiliation: Santiago de Compostela University|
|Gender: F □ M ý|
|Year of the PhD title: 2000|
|Personal web page: http://www.usc.es/ciqus/en/groups/combiomed|
|Previous COST participation: No □ Yes ý|
List of 10 selected publications within last 5 years
|1. J. Med. Chem., 2016, 59, 1967-1983|
|2. Fut. Med. Chem., 2015, 7, 1373-1380|
|3. J. Med. Chem., 2011, 54, 457-471|
|4. ChemBioChem. 2014, 15, 1471-1480|
|5. ACS Med. Chem. Lett., 2013, 4, 1031-1036|
|6. Eur. J. Med. Chem., 2013, 59, 235-242|
|7. J. Org. Chem., 2013, 78, 4402-4409|
|8. J. Org. Chem., 2015, 80, 1533-1549|
|9. J. Cat., 2016, 334, 110-115|
|10. ACS Comb. Sci., 2014, 16, 403-411|
Main skills and expertise (up to 5)
|1. Lead generation and Lead Optimization using Multicomponent Reactions|
|2. Multicomponent-Assisted Multi-target Optimization|
|3. Development and Optimization of Molecular Probes (Fluorescent ligands, bivalent ligands . . )|
|4. Library Generation|
|5. Experimental validation of Computational predictions|
Main equipment/facilities available in the participants’ lab (up to 5)
|1. Library of Heterocyclic Compounds (≈ 3000 Cpds) Assembled by Multicomponent Reactions|
|2. State of the Art Synthesis Laboratory (Microwave Synth., ComBiFlash, etc.).|
|3. Portfolio of near 50 Multicomponent Reactions For Drug Discovery Programs|
|4. Analytical and Structural Facilities (NMR, Mass, HPLC, Circular Dichroism)|
Short personal activity proposal for the COST Action CA15135 (max 1000 characters)
The research proposal of our research group focus on the following points:
1- We propose to cede part of our library of heterocyclic compounds (≈ 3000 Cpds) to the computational and biological/pharmacological groups interested to collaborate. Our library is a collection of heterocyclic compounds (≈ 3000 Cpds) assembled by multicomponent reactions.
2- We propose to collaborate with computational groups in the synthesis and validation of virtual screening predictions.
3- We propose to collaborate in the implementation of mul-titarget optimization process of previously identified hit compounds.
4- We propose to synthesize and optimize ad hoc molecular probes (e.g. fluorescent ligands, homo-bivalent, hetero-bivalent or bitopic ligands, etc.).
5- We could host Ph D. students and post-doctoral researchers, providing training in MCR chemistry and other advanced synthetic methodologies.
6- We could organize one of the actions meeting in Santiago de Compostela (Spain).
Work Group preference: score from 1 (preferred) to 4 (not preferred)
|Work Group of the CA15135 COST Action||Score|
|WG1: Development of new chemical entities||1|
|WG2: Selection of biological targets and assessment of biological data||4|
|WG3: Development of chemical databases||2|
|WG4: Development of Computational methods for multiple ligand design and discovery||2|