Mu.Ta.Lig - COST ACTION CA15135

Prof. Eddy SOTELO

5 December 2016


General information

Name: Eddy
Surname: Sotelo
Cell phone number with international prefix: +34-639888525
Country: Spain
Affiliation: Santiago de Compostela University
Gender: F □ M ý
Year of the PhD title: 2000
Personal web page:
Previous COST participation: No □ Yes ý


List of 10 selected publications within last 5 years

1. J. Med. Chem., 2016, 59, 1967-1983
2. Fut. Med. Chem., 2015, 7, 1373-1380
3. J. Med. Chem., 2011, 54, 457-471
4. ChemBioChem. 2014, 15, 1471-1480
5.  ACS Med. Chem. Lett., 2013, 4, 1031-1036
6. Eur. J. Med. Chem., 2013, 59, 235-242
7. J. Org. Chem., 2013, 78, 4402-4409
8. J. Org. Chem., 2015, 80, 1533-1549
9. J. Cat., 2016, 334, 110-115
10. ACS Comb. Sci., 2014, 16, 403-411


Main skills and expertise (up to 5)

1. Lead generation and Lead Optimization using Multicomponent Reactions
2. Multicomponent-Assisted Multi-target Optimization
3. Development and Optimization of Molecular Probes (Fluorescent ligands, bivalent ligands . . )
4. Library Generation
5. Experimental validation of Computational predictions


Main equipment/facilities available in the participants’ lab (up to 5)

1. Library of Heterocyclic Compounds (≈ 3000 Cpds) Assembled by Multicomponent Reactions
2. State of the Art Synthesis Laboratory (Microwave Synth., ComBiFlash, etc.).
3. Portfolio of near 50 Multicomponent Reactions For Drug Discovery Programs
4. Analytical and Structural Facilities (NMR, Mass, HPLC, Circular Dichroism)



Short personal activity proposal for the COST Action CA15135 (max 1000 characters)


The research proposal of our research group focus on the following points:


1-      We propose to cede part of our library of heterocyclic compounds (≈ 3000 Cpds) to the computational and biological/pharmacological groups interested to collaborate. Our library is a collection of heterocyclic compounds (≈ 3000 Cpds) assembled by multicomponent reactions.


2-      We propose to collaborate with computational groups in the synthesis and validation of virtual screening predictions.


3-      We propose to collaborate in the implementation of mul-titarget optimization process of previously identified hit compounds.


4-      We propose to synthesize and optimize ad hoc molecular probes (e.g. fluorescent ligands, homo-bivalent, hetero-bivalent or bitopic ligands, etc.).


5-      We could host Ph D. students and post-doctoral researchers, providing training in MCR chemistry and other advanced synthetic methodologies.


6-      We could organize one of the actions meeting in Santiago de Compostela (Spain).


Work Group preference: score from 1 (preferred) to 4 (not preferred)

Work Group of the CA15135 COST Action Score
WG1: Development of new chemical entities 1
WG2: Selection of biological targets and assessment of biological data 4
WG3: Development of chemical databases 2
WG4: Development of Computational methods for multiple ligand design and discovery 2